Season Two of NCIS: New Orleans premiered on 22 September 2015 at 9 pm in the US after NCIS. The season will likely conclude around May 2016.
|Dwayne Cassius Pride||Scott Bakula||Special Agent in charge of the NCIS New Orleans office, NCIS/Senior Special Agent|
|Christopher LaSalle||Lucas Black||Senior Special Agent, New Orleans Office, NCIS|
|Meredith Brody||Zoe McLellan||Special Agent, New Orleans Office, NCIS|
|Sebastian Lund||Rob Kerkovich||Forensic Specialist, Jefferson Parrish Coroner's office|
|Patton Plame||Daryl "Chill" Mitchell||Computer Specialist, New Orleans Office, NCIS|
|Sonja Percy||Shalita Grant||Special Agent, New Orleans Office, NCIS, Formerly ATF Agent|
|Dr. Loretta Wade||C. C. H. Pounder||Medical Examiner, Jefferson Parrish Coroner's office|